They reported in Journal of Palliative Medicine that 5 mg twice daily would be an appropriate dose to test in a definitive study. Ten patients provided consent.
After a three-day assessment, patients received titrated methylphenidate hydrochloride at doses ranging from 5 mg a day to 15mg twice a day. Nine patients completed eight days and five received the maximum dose at day 15. Three patients were satisfied with the results at a lower dose and were not willing to increase it.
The team noted a pattern of rapidly improving fatigue and depression at 5 mg twice daily.
Journal of Palliative Medicine, Volume 13, Number 10, Oct. 2010